Raskin A, Crook T H
Arch Gen Psychiatry. 1975 May;32(5):643-9. doi: 10.1001/archpsyc.1975.01760230109008.
Differential effects of chlorpromazine, imipramine hydrochloride, and a placebo were examined in 159 black and 555 white depressed patients in a multihospital collaborative study. In making these comparisons, the effects of age and social class were controlled. The major study findings were the differential effects of the active drugs for the black men and women. Chlorpromazine was the most efficacious treatment for black women, whereas imipramine was most efficacious for black men. These differences occurred on global ratings of improvement as well as on specific symptoms such as depression, anxiety, guilt-worthlessness, sleep disturbances, and social participation. Black patients also evidenced a higher improvement rate at one week, irrespective of treatment, than did the white patients.
在一项多医院合作研究中，对159名黑人抑郁症患者和555名白人抑郁症患者，研究了氯丙嗪、盐酸丙咪嗪和安慰剂的不同疗效。在进行这些比较时，年龄和社会阶层的影响得到了控制。主要研究结果是活性药物对黑人男性和女性的不同疗效。氯丙嗪对黑人女性是最有效的治疗药物，而丙咪嗪对黑人男性最有效。这些差异体现在总体改善评分以及抑郁、焦虑、内疚感、睡眠障碍和社交参与等特定症状上。无论接受何种治疗，黑人患者在一周时的改善率也高于白人患者。
