Wu X, Zhang Z, Shi D
Cancer Hospital of Shanghai Medical University.
Zhonghua Yi Xue Za Zhi. 1998 Apr;78(4):275-7.
To determine the relationship between NDPK(A) expression and retroperitoneal lymph node metastasis (LNM) and the significance of the prognosis in epithelial ovarian carcinoma.
NDPK(A) expression of formalin-fixed parafin-beded samples, which included 74 primary, 31 intraperitoneal and 18 retroperitoneal lymph node metastatic tumors, were examined by ABC immunohistochemisty in 74 patients with primary ovarian cancer.
In the 74 primary lesions, 22 samples showed positive staining of NDPK(A) (30%). Positive staining was higher in patients without LNM(46%) than those with LNM (17%, P = 0.008); it was lower in menopausal patients (19%) than in menstruant (44%, P = 0.022). Compared with primary tumor, NDPK(A) expression appeared to decrease in lymph-node lesion(28% vs 39%, P > 0.1) but to increase in intraperitoneal metastastic tumor (32% vs. 19%, P > 0.5). Multivariance analysis confirmed that the important risk factors for LNM were lower expression of NDPK(A), more large residual tumor and poor differentiation. But there was no any corelation between NDPK(A) expression and survia.
The study suggested that increased expression of NDPK(A)/nm23H1 is inversely related to LNM in epithelial ovarian carcinoma, but it can not confirm the prognostic significance of NDPK(A).
探讨NDPK（A）表达与上皮性卵巢癌腹膜后淋巴结转移（LNM）的关系及其对预后的意义。
采用ABC免疫组化法检测74例原发性卵巢癌患者的福尔马林固定石蜡包埋标本中NDPK（A）的表达，其中包括74例原发性肿瘤、31例腹腔内转移肿瘤和18例腹膜后淋巴结转移肿瘤。
在74例原发性病变中，22例样本NDPK（A）染色呈阳性（30%）。无LNM患者的阳性染色率（46%）高于有LNM患者（17%，P = 0.008）；绝经患者的阳性染色率（19%）低于月经患者（44%，P = 0.022）。与原发性肿瘤相比，NDPK（A）表达在淋巴结病变中似乎降低（28%对39%，P > 0.1），但在腹腔转移肿瘤中升高（32%对19%，P > 0.5）。多因素分析证实，LNM的重要危险因素是NDPK（A）表达降低、残留肿瘤较大和分化差。但NDPK（A）表达与生存率之间无任何相关性。
本研究提示，上皮性卵巢癌中NDPK（A）/nm23H1表达增加与LNM呈负相关，但不能确定NDPK（A）对预后的意义。
