Shi H, He R, Qiu W
School of Stomatology, Shanghai Second Medical University.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1997 Jan;32(1):4-6.
The nm23 gene products, nucleoside diphosphate kinase (NDPK), expression in salivary adenoid cystic carcinoma (ACC) was evaluted by using LSAB immunohistochemical method. Of 25 cases tested, 16 (64.0%) showed positive staining, in which, higher incidence of positive staining was found in ACC without lung metastasis (88.2%, 15/17) than in that with lung metastasis (12.5%, 1/8; P < 0.01). Expression of NDPK/nm23 was correlated with the P-TNM pattern (P < 0.05), otherwise it was not correlated with pathologic types (P > 0.05). The result suggest that the nm23/NDPK may play a role in suppressing the metastatic potential in ACC.
采用LSAB免疫组化方法评估nm23基因产物核苷二磷酸激酶（NDPK）在涎腺腺样囊性癌（ACC）中的表达。在检测的25例病例中，16例（64.0%）呈阳性染色，其中，无肺转移的ACC阳性染色发生率（88.2%，15/17）高于有肺转移的ACC（12.5%，1/8；P<0.01）。NDPK/nm23的表达与P-TNM模式相关（P<0.05），否则与病理类型无关（P>0.05）。结果表明，nm23/NDPK可能在抑制ACC的转移潜能中发挥作用。
