Berney A, Stiefel F, Mazzocato C, Buclin T
Service de Psychiatrie de Liaison, CHUV, Lausanne, Switzerland.
Support Care Cancer. 2000 Jul;8(4):278-86. doi: 10.1007/s005200000154.
This review covers pharmacokinetics, adverse effects and drug interactions of antidepressants and the indications for them, with the aim of assisting the clinician working in palliative and supportive care in the prescription of such drugs. Practical considerations and decision trees to be used prior to the prescription of an antidepressant are also part of this review. Special emphasis is put on the management of depression, which is frequent in patients with advanced cancer and often remains underdetected and undertreated, or is treated at a stage when there is little time for medication to have an effect.
本综述涵盖了抗抑郁药的药代动力学、不良反应、药物相互作用及其适应证，旨在协助从事姑息治疗和支持性护理的临床医生开具此类药物。抗抑郁药处方前的实际考虑因素和决策树也是本综述的一部分。特别强调了抑郁症的管理，晚期癌症患者中抑郁症很常见，往往未被充分检测和治疗，或者在药物起效时间很少的阶段才进行治疗。
