Reich M G, Razavi D
Service de médecine, centre Oscar-Lambret, Lille, France.
Bull Cancer. 1996 Nov;83(11):891-900.
The review of the literature shows that amphetamines (methylphenidate, dextroamphetamine) have been rarely used in the past, but have been recently introduced in the palliative treatment in oncology. They have stimulating, antidepressive and perhaps coanalgesic effects. They can alleviate sleepiness related to opiates analgesics which are given in chronic pain. Amphetamines may also be a therapeutic option, alone or in association with antidepressant drugs, in the pharmacological management of mood disorders unresponsive to tricyclics or selective serotonin reuptake inhibitors. These treatments are well-tolerated and are rapidly active. This treatment may improve the quality of life and comfort in cancer patients.
文献综述表明，苯丙胺类药物（哌甲酯、右旋苯丙胺）过去很少使用，但最近已被引入肿瘤学的姑息治疗中。它们具有刺激、抗抑郁以及可能的协同镇痛作用。它们可以缓解与慢性疼痛中使用的阿片类镇痛药相关的嗜睡。在三环类药物或选择性5-羟色胺再摄取抑制剂治疗无效的情绪障碍的药物治疗中，苯丙胺类药物单独使用或与抗抑郁药联合使用也可能是一种治疗选择。这些治疗耐受性良好且起效迅速。这种治疗可能会改善癌症患者的生活质量和舒适度。
