长期使用硫唑嘌呤治疗后出现肝细胞癌和局灶性肝糖原贮积症。
Hepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy.
作者信息
Cattan S, Wendum D, Chazouilleres O, Schmitz J, Gendre J P
机构信息
Service d'Hépato-Gastroentérologie, Hôpital Rothschild, Paris, France.
出版信息
Hum Pathol. 2000 Jul;31(7):874-6. doi: 10.1053/hupa.2000.7629.
PMID:10923928
Abstract
A 22-year-old woman without predisposing liver disease developed focal hepatic glycogenosis and hepatocellular carcinoma after 6 years of azathioprine therapy for Crohn's disease. Hepatocellular carcinoma without cirrhosis has previously been described during immunosuppression, but this is the first report of disseminated focal hepatic glycogenosis after long-term azathioprine therapy.
摘要
一名无肝脏疾病易患因素的22岁女性，在接受硫唑嘌呤治疗克罗恩病6年后，出现了局灶性肝糖原贮积症和肝细胞癌。此前曾有免疫抑制期间出现无肝硬化的肝细胞癌的报道，但这是长期硫唑嘌呤治疗后出现播散性局灶性肝糖原贮积症的首例报告。
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