Zhang M, Nurse C A
Department of Biology, McMaster University, 1280 Main St. W., L8S 4K1, Hamilton, Ontario, Canada.
Brain Res. 2000 Jul 28;872(1-2):199-203. doi: 10.1016/s0006-8993(00)02499-9.
Spontaneous voltage fluctuations often occurred during perforated-patch recordings from clustered rat carotid body (CB) chemoreceptors in vitro. This activity sometimes appeared as rhythmic-like spikes, when cluster size exceeded approximately 20 cells. Spike discharge could be augmented or induced by hypoxia or 5-HT (2-10 microM) application, and inhibited by the 5-HT receptor blocker, ketanserin (50-100 microM). Thus, endogenous 5-HT may contribute to spontaneous firing within CB receptor clusters via autocrine/paracrine mechanisms.
在体外对成群的大鼠颈动脉体（CB）化学感受器进行穿孔膜片钳记录时，经常会出现自发性电压波动。当细胞簇大小超过约20个细胞时，这种活动有时会表现为节律性的尖峰。缺氧或应用5-羟色胺（2-10微摩尔）可增强或诱发尖峰放电，并被5-羟色胺受体阻滞剂酮色林（50-100微摩尔）抑制。因此，内源性5-羟色胺可能通过自分泌/旁分泌机制促成CB受体簇内的自发放电。
