Soper H V
Cortex. 1979 Mar;15(1):83-96. doi: 10.1016/s0010-9452(79)80009-x.
In order to assess the roles of the posterior parieto-occipital and principal sulcus cortices in processing spatial information, both with and without delays, monkeys were given lesions of one or the other area or no lesion and tested on a series of conditional discrimination tasks. There were six basic tasks, and the cue locations differed from the response locations within each task. The first two had mixed dimensions in that the location of the cue indicated the color of the correct response alternative or the color of the cue indicated the correct response location. The animals were trained preoperatively on these tasks and then tested for postoperative retention. For the next two tasks color was the only relevant dimension, but different colors were used for the cues and response alternatives. For the final two tasks location was the only relevant dimension. When an animal learned a given task it was subsequently tested on it with a 5-sec. delay. The deficits observed suggest that the roles of these areas can not be expressed simply in terms of spatial or delay functions. No group appeared to be impaired on any delay task on which it was tested. The animals with the posterior cortex removed had a great deal of difficulty in using information from one dimension to identify the correct response alternative by the other dimension, but not when the relevant cue and response dimensions were the same. These results suggest that the posterior parieto-occipital area is involved in making associations across dimensions with in the visual modality. The animals with the principal sulcus removed appeared to have difficulty only when they were required to respond with reference to the colors of the response alternatives. On such tasks the relevant dimension (color) was not available until the presentation of the response array. On the other tasks the correct response location could be determined from the cue presentation alone, that is, before the presentation of the response array. This suggests that these animals had a tendency to respond without reference to the color dimension, but rather just to the presentation of the response array, and therefore a principal sulcus function of inhibiting a response until the appropriate information has been processed.
为了评估顶枕后皮质和中央沟皮质在处理空间信息时（无论有无延迟）所起的作用，给猴子的其中一个区域造成损伤或不造成损伤，然后让它们在一系列条件辨别任务中接受测试。共有六项基本任务，且每个任务中提示位置与反应位置不同。前两项任务具有混合维度，即提示的位置表明正确反应选项的颜色，或者提示的颜色表明正确的反应位置。动物在术前接受这些任务的训练，然后进行术后保持测试。接下来的两项任务中，颜色是唯一相关的维度，但提示和反应选项使用不同的颜色。最后两项任务中，位置是唯一相关的维度。当动物学会一项给定任务后，随后会在5秒延迟的情况下对其进行测试。观察到的缺陷表明，这些区域的作用不能简单地用空间或延迟功能来表述。没有一组在其接受测试的任何延迟任务中表现出受损。去除后皮质的动物在利用一个维度的信息通过另一个维度来识别正确反应选项时存在很大困难，但当相关的提示和反应维度相同时则不存在这种情况。这些结果表明，顶枕后区域参与视觉模式下跨维度的关联。去除中央沟的动物似乎只有在被要求根据反应选项的颜色做出反应时才会有困难。在这类任务中，直到呈现反应阵列时才会有相关维度（颜色）的信息。在其他任务中，仅从提示呈现就能确定正确的反应位置，也就是说，在呈现反应阵列之前。这表明这些动物倾向于不参考颜色维度而做出反应，而是仅仅根据反应阵列的呈现来做出反应，因此中央沟具有一种功能，即抑制反应直到适当的信息被处理完毕。
