Deckel A W, Duffy J D
University of Connecticut Medical School, Mail Code 2103, Department of Psychiatry, Program in Neuroscience, Huntington's Disease Program, 263 Farmington Avenue, Farmington, CT 06030-2103, USA.
Brain Res. 2000 Jul 28;872(1-2):258-61. doi: 10.1016/s0006-8993(00)02506-3.
This experiment used functional transcranial Doppler ultrasonography to demonstrate that blood flow velocity in the anterior cerebral artery is hyporeactive in Huntington's disease (HD) patients during maze testing (P<0.05). These vascular changes are due to tracing, as opposed to problem solving, components of the maze task. Using logistic regression, the reactivity of the ACA during activation is able to categorize patients as being either gene negative, or positive, for HD (P=0.0007). The possible role that nitric oxide/peroxynitrite may play in this phenomena is discussed.
本实验采用功能性经颅多普勒超声检查，以证明亨廷顿舞蹈病（HD）患者在迷宫测试期间大脑前动脉的血流速度反应性降低（P<0.05）。这些血管变化是由于迷宫任务中的追踪部分，而非解决问题部分所致。使用逻辑回归分析，激活期间大脑前动脉的反应性能够将HD患者分类为基因阴性或阳性（P=0.0007）。文中还讨论了一氧化氮/过氧亚硝酸盐在这一现象中可能发挥的作用。
