哮喘儿童中针对屋尘螨的特异性IgG亚类抗体的意义

Significance of specific IgG subclass antibodies to house dust mites in asthmatic children.

作者信息

Tang R B, Tsai L C, Chao P L, Hung M W

机构信息

Department of Pediatrics, Taipei Veterans General Hospital, Taiwan, ROC.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 2000 Jun;63(6):440-6.

PMID:10925533

Abstract

BACKGROUND

Dermatophagoides pteronyssinus (Dp) and Dermatophagoides farinae (Df), the major components of house dust, are considered to be etiologic factors of extrinsic asthma. The relationships between immunoglobulin (Ig) G subclass antibodies specific for Dp (or Df) were compared in specific IgE-positive and -negative asthmatic children.

METHODS

Serum levels of IgG and IgE subclass antibodies specific for Dp and Df were studied in 52 children (age, 3-13 years; mean age, 8.4 years) with asthma using enzyme-linked immunosorbent assays. The skin prick test was also used in diagnosis of the reactivity of allergic disease.

RESULTS

The levels of serum-specific IgG1 and IgG2 to Dp and Df in mite-specific IgE-(or skin-test) positive asthmatic children were significantly higher than those in mite-specific IgE- (or skin test) negative children (p < 0.01). Significant correlations between the level of the specific IgE and IgG1 (r = 0.6067; p = 0.0001) or IgG2 (r = 0.5851; p = 0.0002) to Dp, and IgG1 (r = 0.3823; p = 0.0214) or IgG2 (r = 0.5057; p = 0.0017) to Df were found. The specific IgE level and skin test reactivity showed a high correlation of greater than 96% (50/52).

CONCLUSIONS

The levels of mite-specific IgG subclasses were partially compatible to specific IgE levels and skin test reactivity. We conclude that house dust mite allergy is significantly associated with specific IgG1, IgG2 and IgE responses.

摘要

背景

屋尘的主要成分户尘螨（Dp）和粉尘螨（Df）被认为是外源性哮喘的病因。比较了特异性IgE阳性和阴性哮喘儿童中针对Dp（或Df）的免疫球蛋白（Ig）G亚类抗体之间的关系。

方法

采用酶联免疫吸附测定法研究了52例哮喘儿童（年龄3 - 13岁；平均年龄8.4岁）血清中针对Dp和Df的IgG和IgE亚类抗体水平。皮肤点刺试验也用于诊断过敏性疾病的反应性。

结果

螨特异性IgE（或皮肤试验）阳性哮喘儿童血清中针对Dp和Df的特异性IgG1和IgG2水平显著高于螨特异性IgE（或皮肤试验）阴性儿童（p < 0.01）。发现针对Dp的特异性IgE水平与IgG1（r = 0.6067；p = 0.0001）或IgG2（r = 0.5851；p = 0.0002），以及针对Df的IgG1（r = 0.3823；p = 0.0214）或IgG2（r = 0.5057；p = 0.0017）之间存在显著相关性。特异性IgE水平与皮肤试验反应性显示出大于96%（50/52）的高度相关性。