Niskanen L, Voutilainen-Kaunisto R, Teräsvirta M, Karvonen M K, Valve R, Pesonen U, Laakso M, Uusitupa M I, Koulu M
Department of Clinical Nutrition, University of Kuopio, Finland.
Exp Clin Endocrinol Diabetes. 2000;108(3):235-6. doi: 10.1055/s-2000-7748.
In this study we tested the hypothesis that the Leu7Pro7 polymorphism in prepro neuropeptide Y (NPY) gene could be a risk marker for the development of diabetic retinopathy and analyzed a well characterized cohort of patients with Type 2 diabetes followed-up for 10 years from the time of diagnosis. The frequency of Leu7/Pro7-polymorphism was 9.3% (8 out of 86). At baseline, the frequency of retinopathy in patients with the Leu7/Pro7-polymorphism was 25% (2 out of 8) and in those without it 6.4% (5 out of 78) (p=0.126). At 10-year the respective figures were 88% and 50% (p=-0.040). The odds ratio for Leu7/Pro7-polymorphism in logistic regression analysis adjusted for age, gender and HbA1c was 8.97 (95% confidence intervals 1.09-98.0; p=0.049). Our finding based on elderly Finnish Type 2 diabetic subjects suggests that the Leu7Pro7-genotype in preproNPY gene is associated with the development of diabetic retinopathy.
在本研究中，我们检验了如下假设：前神经肽Y（NPY）基因中的Leu7Pro7多态性可能是糖尿病视网膜病变发生的风险标志物，并分析了一组特征明确的2型糖尿病患者队列，从诊断时起随访10年。Leu7/Pro7多态性的频率为9.3%（86例中有8例）。基线时，Leu7/Pro7多态性患者的视网膜病变频率为25%（8例中有2例），无该多态性的患者为6.4%（78例中有5例）（p = 0.126）。10年后，相应数字分别为88%和50%（p = -0.040）。在对年龄、性别和糖化血红蛋白进行校正的逻辑回归分析中，Leu7/Pro7多态性的优势比为8.97（95%置信区间1.09 - 98.0；p = 0.049）。我们基于芬兰老年2型糖尿病受试者的研究结果表明，前神经肽Y基因中的Leu7Pro7基因型与糖尿病视网膜病变的发生有关。
