Sironi M, Isimbaldi G, Claren R, Delpiano C, Di Nuovo F, Spinelli M
Department of Pathology, S. Corona Hospital, Azienda Ospedaliera G. Salvini, Garbagnate Milanese, Italy.
Pathol Res Pract. 2000;196(7):511-7. doi: 10.1016/s0344-0338(00)80053-9.
Manifesting a putative origin from a pleomorphic adenoma, carcinosarcoma of the salivary gland is a heterologous neoplasm in which a sarcomatous and a carcinomatous component coexist. We present a parotid gland carcinosarcoma in a 77-year-old man with peculiar morphological findings. Fine-needle aspiration cytology allowed a preoperative diagnosis of poorly differentiated carcinoma. At histologic examination, the tumor showed biphasic differentiation with an epithelial component made up of well-differentiated keratinizing squamous carcinoma and ductal-type adenocarcinoma, and a mesenchymal component, revealing focal areas of osteosarcoma and myoepithelial malignant proliferation. Carcinosarcoma is a very rare malignant neoplasm, accounting for 0.16% of malignant salivary gland tumors: only 60 cases have been reported, some of which arose "de novo", i.e., without clinico-pathologic evidence of a pre- or co-existing pleomorphic adenoma.
涎腺癌肉瘤被认为起源于多形性腺瘤，是一种异质性肿瘤，其中肉瘤成分和癌成分共存。我们报告一例77岁男性腮腺癌肉瘤，具有独特的形态学表现。细针穿刺细胞学检查术前诊断为低分化癌。组织学检查显示肿瘤呈双相分化，上皮成分由高分化角化鳞状癌和导管型腺癌组成，间叶成分显示骨肉瘤和肌上皮恶性增殖的局灶区域。癌肉瘤是一种非常罕见的恶性肿瘤，占涎腺恶性肿瘤的0.16%：仅报道过60例，其中一些为“新发”，即没有临床病理证据表明存在先前或同时存在的多形性腺瘤。
