Latkovich P, Johnson R L
Department of Pathology, Berkshire Medical Center, Pittsfield, Mass 01201, USA.
Arch Pathol Lab Med. 1998 Aug;122(8):743-6.
True malignant mixed tumors (carcinosarcomas) of salivary gland origin are exceedingly rare and demonstrate malignant epithelial and stromal components. We report a case of parotid gland carcinosarcoma that showed squamous cell carcinoma and malignant fibrous hystiocytoma without clinical or histologic evidence of a preexisting pleomorphic adenoma. This tumor consisted of 2 histologically different populations of cells without evidence of a common origin from the myoepithelial cell, which is the putative precursor cell of pleomorphic adenoma and its derived carcinosarcoma. In addition to supplementing the literature, this case report includes cytohistologic and immunohistochemical analyses that provide further insights into the variable histogenesis of this neoplasm and the distinction between de novo carcinosarcoma and carcinosarcoma originating from pleomorphic adenoma.
涎腺来源的真性恶性混合瘤（癌肉瘤）极为罕见，具有恶性上皮和间质成分。我们报告一例腮腺癌肉瘤，其表现为鳞状细胞癌和恶性纤维组织细胞瘤，无先前存在的多形性腺瘤的临床或组织学证据。该肿瘤由两种组织学上不同的细胞群组成，没有证据表明它们起源于肌上皮细胞，而肌上皮细胞是多形性腺瘤及其衍生癌肉瘤的假定前体细胞。除了补充文献外，本病例报告还包括细胞组织学和免疫组化分析，这些分析为该肿瘤的可变组织发生以及新发癌肉瘤与起源于多形性腺瘤的癌肉瘤之间的区别提供了进一步的见解。
