Khan W I, Sultana R, Rahman M, Akhter H, Haq J A, Ali L, Mohsin M A, Khan A K
Department of Immunology, National Diagnostic Network, Panthopath, Dhaka, Bangladesh.
Asian Pac J Allergy Immunol. 2000 Jun;18(2):99-103.
Infections due to hepatitis A (HAV), hepatitis B (HBV), hepatitis C (HCV) and hepatitis E (HEV) viruses are the major causes of hepatitis and are associated with significant morbidity and mortality in developing countries like Bangladesh. The present study was carried out to determine the prevalence of HBsAg, anti-HCV antibody, anti-HAV antibody and anti-HEV antibody in patients suspected of having infection by HBV, HCV, HAV and HEV, respectively. Antibody to HAV was detected in 39% of subjects investigated. HBsAg was identified in 19% of subjects. Antibody to HCV and HEV was detected in 13% and 53% subjects, respectively. Infection with HAV was very high among children < or = 6 years of age (100%). On the contrary, exposure to HEV was higher in adult persons > or => 30 years of age (52%) compared to that in children < or = 6 years of age who had 0% incidence. Our study clearly indicates a high prevalence of those viruses, particularly of enterically transmitted HAV and HEV in Bangladesh, which appeared to be a serious health problem in this developing country. Control measures should be taken on an urgent basis to prevent the spread of infections by these viruses.
甲型肝炎病毒（HAV）、乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和戊型肝炎病毒（HEV）感染是肝炎的主要病因，在孟加拉国等发展中国家与显著的发病率和死亡率相关。本研究旨在分别确定疑似感染HBV、HCV、HAV和HEV的患者中HBsAg、抗HCV抗体、抗HAV抗体和抗HEV抗体的流行情况。在39%的受调查对象中检测到抗HAV抗体。在19%的受调查对象中检测到HBsAg。分别在13%和53%的受调查对象中检测到抗HCV抗体和抗HEV抗体。在6岁及以下儿童中HAV感染率非常高（100%）。相反，30岁及以上成年人中HEV暴露率（52%）高于6岁及以下儿童，后者的发病率为0%。我们的研究清楚地表明，在孟加拉国这些病毒的流行率很高，尤其是经肠道传播的HAV和HEV，这在这个发展中国家似乎是一个严重的健康问题。应立即采取控制措施以防止这些病毒感染的传播。
