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连续脊髓麻醉/镇痛用于接受胃成形术剖腹手术的病态肥胖患者的围手术期管理。

Continuous spinal anesthesia/analgesia for perioperative management of morbidly obese patients undergoing laparotomy for gastroplastic surgery.

作者信息

Michaloudis D, Fraidakis O, Petrou A, Farmakalidou H, Neonaki M, Christodoulakis M, Flossos A, Bakos P, Melissas J

机构信息

Department of Anesthesiology, University Hospital Crete, Greece.

出版信息

Obes Surg. 2000 Jun;10(3):220-9. doi: 10.1381/096089200321643494.

Abstract

BACKGROUND

The authors determined prospectively the safety of continuous spinal anesthesia combined with general anesthesia and the efficacy of postoperative pain relief with continuous spinal analgesia for morbidly obese patients undergoing vertical banded gastroplasty.

METHODS

27 patients (13 men, 14 women) with a mean body mass index (BMI) of 50.4 +/- 7.8 and several co-morbidities were studied. All patients were anesthetized with the same anesthetic regimen, which included midazolam, fentanyl, propofol, muscle relaxants, nitrous oxide, isoflurane and intrathecal bupivacaine. Postoperative pain relief was provided for 5 days and all patients received the same regimen, which included intrathecal bupivacaine, fentanyl and intravenous tenoxicam. The intrathecal analgesic regimen was administered continuously through a pump which had the facility of providing bolus doses when requested in predetermined lockout intervals. Intra-operative monitoring included hemodynamic and respiratory parameters. Additional postoperative monitoring included respiratory rate, degree of sedation, sensory level of anesthesia, motor response and intensity of pain.

RESULTS

Intraoperative anesthetic technique was safe and provided satisfactory results in the immediate postoperative period. Furthermore, the postoperative analgesia regimen provided effective analgesia in all patients. The mean doses of fentanyl and bupivacaine infused intrathecally for the first 24 postoperative hours were 14.1 +/- 2.0 microg.h(1) and 0.7 +/- 0.1 mg.h(1) respectively, while the requirements of analgesia decreased progressively with time. The technique provided effective analgesia with low pain scores, which was reflected by ease in mobilizing and performing physical exercises with the physiotherapist. Only minor complications related to anesthesia and analgesia were encountered.

CONCLUSION

To our knowledge, this technique of anesthesia and postoperative analgesia has not been described before in morbidly obese patients. This regimen merits further controlled trials to establish its place in the perioperative management of morbidly obese patients.

摘要

背景

作者前瞻性地确定了连续脊髓麻醉联合全身麻醉对病态肥胖患者行垂直捆扎胃成形术的安全性以及连续脊髓镇痛术后疼痛缓解的效果。

方法

研究了27例患者(13例男性,14例女性),平均体重指数(BMI)为50.4±7.8,伴有多种合并症。所有患者均采用相同的麻醉方案,包括咪达唑仑、芬太尼、丙泊酚、肌肉松弛剂、氧化亚氮、异氟烷和鞘内布比卡因。术后疼痛缓解持续5天,所有患者接受相同方案,包括鞘内布比卡因、芬太尼和静脉注射替诺昔康。鞘内镇痛方案通过一个泵持续给药,该泵具备在预定锁定间隔内根据需要提供大剂量药物的功能。术中监测包括血流动力学和呼吸参数。术后额外监测包括呼吸频率、镇静程度、麻醉感觉平面、运动反应和疼痛强度。

结果

术中麻醉技术安全,术后即刻效果令人满意。此外,术后镇痛方案在所有患者中均提供了有效的镇痛效果。术后第1个24小时鞘内注入的芬太尼和布比卡因的平均剂量分别为14.1±2.0微克·小时⁻¹和0.7±0.1毫克·小时⁻¹,而镇痛需求随时间逐渐减少。该技术提供了有效的镇痛,疼痛评分较低,这体现在与物理治疗师一起活动和进行体育锻炼时的轻松程度上。仅遇到了与麻醉和镇痛相关的轻微并发症。

结论

据我们所知,这种麻醉和术后镇痛技术此前尚未在病态肥胖患者中描述过。该方案值得进一步进行对照试验,以确定其在病态肥胖患者围手术期管理中的地位。

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