Lockard J S, Ojemann G A, Congdon W C, DuCharme L L
Epilepsia. 1979 Jun;20(3):223-34. doi: 10.1111/j.1528-1157.1979.tb04799.x.
The efficacy of cerebellar stimulation was addressed in a chronic monkey model (N = 12) of spontaneous focal motor and secondarily generalized seizures using 24 hr seizure frequency monitoring and all-night EEG recording. The anterior cerebellar vermis was stimulated employing parameters similar to those used in man, 10 Hz, 1 msec pulses, 10 min on, 10 off, at an average current of 2.0 mA. Six weeks pre- and post-base-line periods were compared to a stimulation period of the same length. The results contribute to a clarification of conflicting findings of previous researchers by revealing an inverse relationship between seizure frequency and interictal EEG bursts during the weeks of stimulation. Seizure frequency increased significantly and interictal bursts decreased. Both of these effects (especially the former) were evident in the post-stimulation period, but for different reasons than hypothesized for the period of stimulation. Whereas the therapeutic value of cerebellar stimulation on seizures may be in question, its utilization in the study of mechanisms of epilepsy may be warranted.
利用24小时癫痫发作频率监测和整夜脑电图记录，在自发性局灶性运动性癫痫和继发性全身性癫痫的慢性猴子模型（N = 12）中探讨了小脑刺激的疗效。采用与人使用的参数相似的参数刺激小脑蚓部前部，即10赫兹、1毫秒脉冲、开10分钟、关10分钟，平均电流为2.0毫安。将基线期前后六周与相同长度的刺激期进行比较。这些结果通过揭示刺激期间几周内癫痫发作频率与发作间期脑电图爆发之间的反比关系，有助于澄清先前研究人员相互矛盾的发现。癫痫发作频率显著增加，发作间期爆发减少。这两种效应（尤其是前者）在刺激后阶段很明显，但原因与刺激期间的假设不同。虽然小脑刺激对癫痫发作的治疗价值可能存在疑问，但在癫痫机制研究中使用它可能是有必要的。
