慢性小脑刺激对猴子慢性边缘叶癫痫发作的影响。

Effects of chronic cerebellar stimulation on chronic limbic seizures in monkeys.

作者信息

Strain G M, Babb T L, Soper H V, Perryman K M, Lieb J P, Crandall P H

出版信息

Epilepsia. 1979 Dec;20(6):651-64. doi: 10.1111/j.1528-1157.1979.tb04849.x.

DOI:10.1111/j.1528-1157.1979.tb04849.x

Abstract

No influences of chronic cerebellar stimulation were found in 10 different controlled experiments in 5 different monkeys with chronic alumina-induced psychomotor seizures. The stimulation parameters used were comparable to those used in human epileptics, and continuous daily EEG and behavioral monitoring allowed all seizures to be measured for daily frequency and duration over the several weeks of the experiments. Nocturnal seizures were similarly quantified in 3 monkeys to verify that cerebellar stimulation did not affect them. Motor cortex potentials evoked by cerebellar pulses confirmed that the stimulations were activating the cerebellum throughout the experiments, and measures of electrode access resistance and impedance verified that the electrodes remained in contact with the cerebellum. In one monkey given phenobarbital medication, interictal morbid behavior appeared to be improved by chronic stimulation of either cerebellum or dorsolateral frontal cortex, thus indicating an arousal influence of brain stimulation not due to cerebellum per se.

摘要

在5只患有慢性氧化铝诱导的精神运动性癫痫的不同猴子身上进行的10项不同的对照实验中，未发现慢性小脑刺激有任何影响。所使用的刺激参数与用于人类癫痫患者的参数相当，并且连续每日的脑电图和行为监测使得能够在实验的几周内测量所有癫痫发作的每日频率和持续时间。在3只猴子中对夜间发作进行了类似的量化，以验证小脑刺激不会对其产生影响。小脑脉冲诱发的运动皮层电位证实，在整个实验过程中刺激均激活了小脑，并且电极接入电阻和阻抗的测量结果证实电极与小脑保持接触。在一只接受苯巴比妥药物治疗的猴子中，慢性刺激小脑或背外侧额叶皮层似乎改善了发作间期的病态行为，因此表明脑刺激的唤醒作用并非源于小脑本身。