Carney D E, Tweddell E D
Med J Aust. 1975 Jan 4;1(1):13-5.
Obese patients encountered in general practice were studied in order to determine whether a long-acting form of diethylpropion hydrochloride (Tenuate Dospan) was more effective than placebo for weight loss. One hundred and two patients completed this double blind, 16-week crossover study. During the first eight weeks, the patients treated with diethylpropion hydrochloride lost significantly (P smaller than 0.001) more weight than the patients treated with placebo (an average of 11-1 lb or 6-4% of their initial weight as compared with 6-2 lb or 3-6% of their initial weight). When the group taking diethylpropion hydrochloride crossed over to placebo for a second eight weeks, they lost an average of 1-5 lb (0-9% of their weight at the start of the second period), while the group who crossed from placebo over to diethylpropion hydrochloride lost an average of 6-7 lb (3-8%). The advantages of diethylpropion hydrochloride over placebo are statistically significant.
为了确定长效盐酸二乙丙胺（Tenuate Dospan）在减肥方面是否比安慰剂更有效，对普通诊所中遇到的肥胖患者进行了研究。102名患者完成了这项双盲、为期16周的交叉研究。在头八周内，接受盐酸二乙丙胺治疗的患者体重减轻显著（P小于0.001），比接受安慰剂治疗的患者多（平均减轻11.1磅或初始体重的6.4%，而接受安慰剂治疗的患者平均减轻6.2磅或初始体重的3.6%）。当服用盐酸二乙丙胺的组在接下来的八周改用安慰剂时，他们平均体重减轻了1.5磅（第二阶段开始时体重的0.9%），而从安慰剂组改用盐酸二乙丙胺的组平均体重减轻了6.7磅（3.8%）。盐酸二乙丙胺相对于安慰剂的优势具有统计学意义。
