硝基咪唑类的诱变作用。II. 2-硝基咪唑类的效应。

The mutagenic action of nitroimidazoles. II. Effects of 2-nitroimidazoles.

作者信息

Voogd C E, Van der Stel J J, Jacobs J J

出版信息

Mutat Res. 1975 Jun;31(3):149-52. doi: 10.1016/0165-1161(75)90083-7.

Abstract

The 2-nitroimidazoles Ro-71051 (N-benzyl-2-nitro-1-imidazole-acetamide) and Ro-5-9963 (3(2-nitro-1-imidazolyl)-1,2-propanediol) increased the mutation rate of a Klebsiella pneumoniae mutant to streptomycin-resistance including streptomycin-dependence in Luria and Delbruck's fluctuation test in concentrations of 0.05-1 mM and 0.02-0.2 mM respectively. The 2-nitroimidazole, azomycin, (Ro-5-9129/001) failed to increase the mutation rate. The results are compared to those obtained with the 5-nitroimidazoles methronidazoles metronidazole, nimorazole and dimetridazole, which caused a degree of increase similar to Ro-7-1051 and Ro-59963.

摘要

2-硝基咪唑类化合物Ro-71051（N-苄基-2-硝基-1-咪唑乙酰胺）和Ro-5-9963（3-(2-硝基-1-咪唑基)-1,2-丙二醇）在卢里亚和德尔布吕克波动试验中，分别以0.05-1 mM和0.02-0.2 mM的浓度提高了肺炎克雷伯菌突变体对链霉素的抗性突变率，包括对链霉素的依赖性。2-硝基咪唑类化合物偶氮霉素（Ro-5-9129/001）未能提高突变率。将这些结果与用5-硝基咪唑类化合物甲硝唑、尼莫唑和地美硝唑获得的结果进行了比较，后者引起的增加程度与Ro-7-1051和Ro-59963相似。