乙烯-炔烃交叉复分解反应的扩展范围：炔丙基位置的配位杂原子官能团

Expanded scope in ethylene-alkyne cross-metathesis: coordinating heteroatom functionality at the propargylic position.

作者信息

Smulik J A, Diver S T

机构信息

Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, USA.

出版信息

Org Lett. 2000 Jul 27;2(15):2271-4. doi: 10.1021/ol006035l.

DOI:10.1021/ol006035l

PMID:10930261

Abstract

The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene-alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-substituted alkynes also react efficiently under the reported conditions.

摘要

格拉布斯1,3-二甲基苯基-4,5-二氢咪唑-2-亚基取代的钌配合物1催化乙烯-炔烃交叉复分解反应，并且已证明其能够耐受炔丙基和高炔丙基位置的游离羟基和配位官能团。受阻且对映体富集的1-取代炔烃在报道的条件下也能有效反应。