Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Org Biomol Chem. 2012 Jan 14;10(2):225-8. doi: 10.1039/c1ob06456h. Epub 2011 Oct 4.
The diarylalkenyl propargylic complex framework has been found in many natural products and medicinal regents. Herein, we have disclosed an unprecedented FeCl(3) catalyzed ene-type reaction of propargylic alcohols with 1,1-diaryl alkenes which enabled us to furnish a diarylalkenyl propargylic complex framework in moderate to high chemical yields (up to 98%).
二芳基烯丙基炔丙基配合物骨架在许多天然产物和药用试剂中都有发现。在此，我们首次公开了三氯化铁催化的炔丙醇与 1,1-二芳基烯烃的 ene 型反应，使我们能够以中等至较高的化学收率（高达 98%）得到二芳基烯丙基炔丙基配合物骨架。
