α-鹅膏菌素：被牛乳铁蛋白过氧化物酶灭活
alpha-Amanitin: inactivation by bovine lactoperoxidase.
作者信息
Morris P W, Kelley K M, Logas W G
出版信息
Experientia. 1979 May 15;35(5):589-91. doi: 10.1007/BF01960335.
PMID:109306
Abstract
The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen peroxide.
摘要
主要的鹅膏毒素，即α-鹅膏蕈碱，被发现对乳过氧化物酶催化的吲哚核降解极为敏感，而非碘化反应。用乳过氧化物酶、碘化物和过氧化氢处理α-鹅膏蕈碱后，其对真核生物DNA依赖性RNA聚合酶II的抑制效力大幅减弱。
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