[上海中国队列中高血压性脑血管病卒中与肾素-血管紧张素系统基因多态性的关联]

[Association between hypertensive cerebrovascular stroke and renin-angiotensin system gene polymorphism from Chinese cohort in Shanghai].

作者信息

Wei X, Wang G, Jiang C, Li D, Zhao G

机构信息

Department of Cardiology Affiliated Zhujiang Hospital the First Military Medical University, Guangzhou, Guangdong, P. R. China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2000 Aug;17(4):256-8.

PMID:10932009

Abstract

OBJECTIVE

To evaluate the association between hypertensive cerebrovascular stroke and renin-angiotensin system gene polymorphism from Chinese cohort.

METHODS

The polymorphisms of angiotensinogen(AGT) and angiotensin-converting enzyme(ACE) from 257 cases of simple essential hypertension(EH) and 218 cases of hypertensive stroke(131 hemorrhagic cases and 87 ischemic cases were detected by PCR-RFLP.

RESULTS

The frequencies of DD genotype and D allele of ACE gene in ischemic stroke were significantly higher than those in hemorrhagic stroke and EH, and the odds ratios(OR) of DD/II genotype were 3.25(2.20-4.79) and 2.87(2.03-4.06), while the OR of D/I allele were 1.83(1.38-2.43) and 1.69(1.27-2.24) respectively. Otherwise, there was no difference in frequency distribution of Met235Thr mutation polymorphism and DD+TT/non DD non TT combined among the three groups.

CONCLUSION

The I/D polymorphism of ACE gene may be one of the risk factors and susceptible genetic markers for ischemic stroke with essential hypertension in Chinese.

摘要

目的

评估中国队列中高血压性脑血管卒中与肾素-血管紧张素系统基因多态性之间的关联。

方法

采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测257例单纯原发性高血压（EH）患者和218例高血压性卒中患者（131例出血性病例和87例缺血性病例）的血管紧张素原（AGT）和血管紧张素转换酶（ACE）基因多态性。

结果

缺血性卒中患者ACE基因的DD基因型和D等位基因频率显著高于出血性卒中和EH患者，DD/II基因型的比值比（OR）分别为3.25（2.20-4.79）和2.87（2.03-4.06），而D/I等位基因的OR分别为1.83（1.38-2.43）和1.69（1.27-2.24）。此外，三组间Met235Thr突变多态性及DD+TT/非DD非TT组合的频率分布无差异。