Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou, PR China.
J Hypertens. 2010 Mar;28(3):419-28. doi: 10.1097/HJH.0b013e32833456b9.
The polymorphisms of angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes have been linked to increased risk of essential hypertension in multiple populations, but the results were inconsistent.
To evaluate the associations of these polymorphisms with essential hypertension, we carried out a meta-analysis of the association studies within Han Chinese population. In this study, we reviewed two most commonly investigated polymorphisms, AGT M235T and ACE I/D, and provided summary estimates regarding their associations with essential hypertension. PubMed and China Biological Medicine Database were searched, and a total of 71 studies (31 studies for AGT M235T and 40 studies for ACE I/D) comprising 10 547 essential hypertension patients and 9217 controls from 23 provinces and special districts in China were finally included in this study.
Statistically significant associations with essential hypertension were identified for TT genotype of AGT M235T polymorphism (odds ratio 1.54, 95% confidence interval 1.16-2.03, P = 0.002) and DD genotype of ACE I/D polymorphism (odds ratio 1.61, 95% confidence interval 1.32-1.98, P < 0.0001). Under dominant, recessive, and additive genetic models, positive associations were also found. The heterogeneity existed among the studies (P < 0.05), whereas the publication bias did not exist in both AGT analysis (P = 0.052) and ACE analysis (P = 0.103).
The present meta-analysis suggests that AGT M235T and ACE I/D modulate the risk of essential hypertension in Han Chinese population.
血管紧张素原（AGT）和血管紧张素转换酶（ACE）基因的多态性与多种人群的原发性高血压风险增加有关，但结果不一致。
为了评估这些多态性与原发性高血压的相关性，我们对汉族人群中的关联研究进行了荟萃分析。在这项研究中，我们回顾了两个最常研究的多态性，AGT M235T 和 ACE I/D，并提供了它们与原发性高血压相关性的综合估计值。我们检索了 PubMed 和中国生物医学文献数据库，最终纳入了来自中国 23 个省、自治区的 71 项研究（31 项研究 AGT M235T，40 项研究 ACE I/D），共包括 10547 例原发性高血压患者和 9217 例对照。
AGT M235T 多态性的 TT 基因型（比值比 1.54，95%置信区间 1.16-2.03，P = 0.002）和 ACE I/D 多态性的 DD 基因型（比值比 1.61，95%置信区间 1.32-1.98，P < 0.0001）与原发性高血压显著相关。在显性、隐性和加性遗传模型下，也发现了阳性关联。研究之间存在异质性（P < 0.05），但在 AGT 分析（P = 0.052）和 ACE 分析（P = 0.103）中均不存在发表偏倚。
本荟萃分析表明，AGT M235T 和 ACE I/D 调节汉族人群原发性高血压的风险。
