Briellmann R S, Torn-Broers Y, Busuttil B E, Major B J, Kalnins R M, Olsen M, Jackson G D, Frauman A G, Berkovic S F
Epilepsy Research Institute, Brain Imaging Research Institute, University of Melbourne, Australia.
Neurology. 2000 Aug 8;55(3):435-7. doi: 10.1212/wnl.55.3.435.
The authors analyzed the association between APOE epsilon4 genotype and clinical and MRI findings in 43 refractory temporal lobe epilepsy patients. The distribution of the alleles were normal. Ten patients (23%) had an APOE epsilon 4 allele and had an earlier onset of habitual seizures (with epsilon4 5 +/- 5 years; without epsilon4 15 +/- 10 years). Quantitative MRI findings were not influenced by the APOE epsilon4 genotype. APOE epsilon4 may shorten the latency between an initial injury and seizure onset.
作者分析了43例难治性颞叶癫痫患者的APOE ε4基因型与临床及MRI表现之间的关联。等位基因分布正常。10例患者（23%）携带APOE ε4等位基因，其习惯性癫痫发作起病较早（携带ε4者为5±5岁；不携带ε4者为15±10岁）。定量MRI表现不受APOE ε4基因型影响。APOE ε4可能会缩短初次损伤与癫痫发作起始之间的潜伏期。
