Sobolewski P, Stankiewicz A
Oddziału Okulistycznego Samodzielnego Publicznego Szpitala Wojewódzkiego w Suwałkach.
Klin Oczna. 2000;102(2):109-13.
Presentation of new waveform analysis of pattern and flash visual evoked potentials (VEPs) in patients with optic neuropathy.
The study involved 48 patients with acute optic neuritis (2nd group), 60 patients with demyelinating (3rd group), 32 patients with compressive (4th group), 24 patients with nonarteritic anterior ischemic optic neuropathy (5th group) and 32 healthy subjects (1st group). Using computer system UTAS E-1000 (pattern and flash stimulation) the VEPs tests were performed. Amplitude, latency of 8 VEP components, 4 gradients, mean waveform and 16 areas of numeric integrals were calculated. Results were analysed with the use of AN-STAT software.
Statistical difference recorded under pattern stimulation was obtained in latency of 3rd, 4th, 5th components of VEP in comparing 3th and 4th groups, as well as amplitude of 3rd waveform, second gradient, areas of integrals between cursors number 2 and 4 in comparing 3rd and 5th groups (p < 0.001). Statistical difference recorded under flash stimulation was obtained in latency of 4th component in comparing 2nd and 5th groups, in amplitude of 7th waveform, areas of integrals covering 160 and 224, 224 and 256 ms, between cursors number 2 and 4 in comparing 4th and 5th groups, as well as in a range of areas of integrals covering 160 and 192 ms in comparing 4th and 5th groups (p < 0.001).
Results prove clinical potency of the presented new comprehensive method in analysis of VEP in optic nerve diseases.
介绍视神经病变患者图形和闪光视觉诱发电位（VEP）的新波形分析。
该研究纳入了48例急性视神经炎患者（第2组）、60例脱髓鞘病变患者（第3组）、32例压迫性病变患者（第4组）、24例非动脉性前部缺血性视神经病变患者（第5组）以及32名健康受试者（第1组）。使用UTAS E - 1000计算机系统（图形和闪光刺激）进行VEP测试。计算了8个VEP成分的振幅、潜伏期、4个梯度、平均波形以及16个数字积分区域。结果使用AN - STAT软件进行分析。
在图形刺激下，比较第3组和第4组时，VEP第3、4、5成分的潜伏期存在统计学差异；比较第3组和第5组时，第3波形的振幅、第二个梯度以及光标2和4之间的积分区域存在统计学差异（p < 0.001）。在闪光刺激下，比较第2组和第5组时，第4成分的潜伏期存在统计学差异；比较第4组和第5组时，第7波形的振幅、覆盖160和224、224和256毫秒的积分区域以及光标2和4之间的积分区域存在统计学差异；比较第4组和第5组时，覆盖160和192毫秒的积分区域范围也存在统计学差异（p < 0.001）。
结果证明了所提出的新综合方法在视神经疾病VEP分析中的临床效用。
