视神经疾病中的图形视网膜电图和视觉诱发电位

Pattern electroretinography and visual evoked potentials in optic nerve diseases.

作者信息

Atilla Huban, Tekeli Oya, Ornek Kemal, Batioglu Figen, Elhan Atilla Halil, Eryilmaz Teksin

机构信息

Department of Ophthalmology, School of Medicine, Ankara University, Ankara, Turkey.

出版信息

J Clin Neurosci. 2006 Jan;13(1):55-9. doi: 10.1016/j.jocn.2005.02.007.

DOI:10.1016/j.jocn.2005.02.007

PMID:16410198

Abstract

BACKGROUND

To evaluate transient pattern electroretinography (PERG) and pattern visual evoked potential (VEP) for the diagnosis, differential diagnosis and follow-up of optic nerve diseases.

METHODS

Twenty-nine consecutive patients (14 female, 15 male) with the diagnosis of ischaemic optic neuropathy (n=14) and optic neuritis (n=15) were included in this study. Mean age of the patients with ischaemic optic neuropathy was 63.3+/-3.3 (60-78) years and the mean age of the patients with optic neuritis was 28.3+/-8.4 (19-43) years. In each patient ophthalmological examination and systemic evaluation were done and VEP and PERG were recorded. As a control group, VEP recordings of 35 healthy subjects were included.

RESULTS

In the ischaemic optic neuropathy group (group 1), mean VEP amplitude (+/-SD) (1.96+/-0.95 microV) was found to be decreased significantly in the affected eyes in comparison to the control group and the unaffected eyes. The delay in latency (116.3+/-20.14 msec in the affected eyes compared with 101.31+/-6.19 msec in unaffected eyes) was statistically significant when compared with the healthy subjects. In the optic neuritis group (group 2), VEP amplitude was decreased (4.13+/-4.04 microV vs 6.97+/-3.35 microV and 6.97+/-4.43 microV) and latency was increased (122.59+/-20.09 msec vs 101.31+/-6.19 msec and 108.76+/-13.57 msec) in affected eyes significantly in comparison to the unaffected eyes and control group, respectively. Even though there were no significant differences for P50 latency and N95/P50 ratios between affected and unaffected eyes in both groups, N95 amplitude decreased significantly in the affected eyes of the ischaemic optic neuropathy patients and N95 latency was found to be decreased in optic neuritis patients. There was no correlation between VEP and PERG findings in both groups.

CONCLUSION

VEP amplitude decreased significantly in ischaemic optic neuropathies while latency delay was more significant in patients with optic neuritis. PERG findings showed decreased N95 amplitude in ischemic optic neuropathy without associated latency changes.

摘要

背景

评估瞬态图形视网膜电图（PERG）和图形视觉诱发电位（VEP）在视神经疾病诊断、鉴别诊断及随访中的应用。

方法

本研究纳入了29例连续患者（14例女性，15例男性），其中缺血性视神经病变患者14例，视神经炎患者15例。缺血性视神经病变患者的平均年龄为63.3±3.3（60 - 78）岁，视神经炎患者的平均年龄为28.3±8.4（19 - 43）岁。对每位患者进行眼科检查和全身评估，并记录VEP和PERG。作为对照组，纳入了35名健康受试者的VEP记录。

结果

在缺血性视神经病变组（第1组）中，患眼的平均VEP波幅（±标准差）（1.96±0.95 μV）与对照组及对侧未患眼相比显著降低。与健康受试者相比，患眼潜伏期延迟（患眼为116.3±20.14毫秒，未患眼为101.31±6.19毫秒）具有统计学意义。在视神经炎组（第2组）中，患眼的VEP波幅降低（4.13±4.04 μV对比6.97±3.35 μV和6.97±4.43 μV），潜伏期延长（122.59±20.09毫秒对比101.31±6.19毫秒和108.76±13.57毫秒），分别与未患眼和对照组相比有显著差异。尽管两组中患眼与未患眼之间的P50潜伏期和N95/P50比值无显著差异，但缺血性视神经病变患者患眼的N95波幅显著降低，视神经炎患者患眼的N95潜伏期降低。两组中VEP和PERG结果之间均无相关性。