Rohan T E, Jain M, Miller A B
Department of Public Health Sciences, University of Toronto, Canada.
Public Health Nutr. 1998 Sep;1(3):139-45. doi: 10.1079/phn19980023.
To study the association between alcohol consumption and risk of benign proliferative epithelial disorders (BPED) of the breast (conditions which are thought to have premalignant potential).
Case-cohort study.
The study was undertaken within the 56,537 women in the Canadian National Breast Screening Study (NBSS) who completed self-administered dietary questionnaires. (The NBSS is a randomized controlled trial of screening for breast cancer in women aged 40-59 years at recruitment.)
The study subjects were the 657 women in the dietary cohort who were diagnosed with biopsy-confirmed incident BPED. For comparative purposes, a subcohort consisting of a random sample of 5681 women was selected from the full dietary cohort. After exclusions for various reasons, the analyses were based on 557 cases and 5028 non-cases.
When compared to non-drinkers, rate ratios (95% CI) for those consuming > 0 and < or =10 g of ethanol day(-1), >10 and < or =20 g day(-1), >20 and < or =30 g day(-1) and >30 g day(-1) were 0.35 (0.27-0.45), 0.26 (0.18-0.39), 0.29 (0.18-0.48), and 0.23 (0.13-0.40), respectively (the associated P value for the trend was 0.089). Similar findings were obtained from analyses conducted separately in the screened and control arms of the NBSS, in premenopausal and postmenopausal women, and for non-atypical and atypical forms of BPED, and there was little difference between the results for screen-detected and interval-detected BPED.
Alcohol consumption was associated with a non-dose-dependent reduction in risk of BPED.
研究饮酒与乳腺良性增生性上皮疾病（BPED，被认为具有癌前病变潜能的病症）风险之间的关联。
病例队列研究。
该研究在加拿大全国乳腺筛查研究（NBSS）中完成自我管理饮食问卷的56,537名女性中进行。（NBSS是一项针对招募时年龄在40 - 59岁女性的乳腺癌筛查随机对照试验。）
研究对象为饮食队列中657名经活检确诊为新发BPED的女性。为作比较，从整个饮食队列中随机抽取5681名女性组成一个子队列。经各种原因排除后，分析基于557例病例和5028例非病例。
与不饮酒者相比，每日摄入乙醇>0且≤10克、>10且≤20克、>20且≤30克以及>30克的人群的率比（95%置信区间）分别为0.35（0.27 - 0.45）、0.26（0.18 - 0.39）、0.29（0.18 - 0.48）和0.23（0.13 - 0.40）（趋势的相关P值为0.089）。在NBSS的筛查组和对照组、绝经前和绝经后女性以及BPED的非非典型和非典型形式中分别进行分析时获得了类似结果，筛查发现的BPED和间期发现的BPED结果之间几乎没有差异。
饮酒与BPED风险的非剂量依赖性降低相关。
