Maurelli M, Candeloro E, Egitto M T, Alfonsi E
Institute of Neurology C. Mondino, University of Pavia, Italy.
Ital J Neurol Sci. 1998 Jun;19(3):184-8. doi: 10.1007/BF00831570.
We present two siblings affected by hereditary motor and sensory type II neuropathy (HMSN-II) with neuromyotonia, and associated with muscle hypertrophy of the thighs and calves in one. We review the literature about the association between HMSN-II, neuromyotonia and muscle hypertrophy. Muscle enlargement in HMSN-II is rare and may be sporadic or under genetic control. In our patient, muscle hypertrophy was sporadic and probably due to neuromyotonia. The relationship between muscle hypertrophy and neuromyotonia can be deduced by the fact that both conditions were reduced after diphenylhydantoin treatment (200 mg/day).
我们报告了两例患有遗传性运动感觉性II型神经病（HMSN-II）并伴有神经肌强直的兄弟姐妹，其中一例还伴有大腿和小腿肌肉肥大。我们回顾了有关HMSN-II、神经肌强直和肌肉肥大之间关联的文献。HMSN-II中的肌肉增大很少见，可能是散发性的或受基因控制。在我们的患者中，肌肉肥大是散发性的，可能是由于神经肌强直。肌肉肥大与神经肌强直之间的关系可以从苯妥英钠治疗（200毫克/天）后这两种情况均有所减轻这一事实推断出来。
