Mitchell G W, Bosch E P, Hart M N
Eur Neurol. 1987;27(3):188-96. doi: 10.1159/000116154.
We encountered 2 patients with hereditary motor and sensory neuropathy (HMSN) type I who had marked weakness developing during several months superimposed on chronic peroneal muscular atrophy. Further studies disclosed a chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in one patient and CIDP associated with polymyositis in the other. Both patients responded to prednisone and azathioprine with substantial improvement. Patients with HMSN who develop rapid progression of weakness should be evaluated for superimposed, potentially treatable dysimmune neuromuscular disorders.
我们遇到了2例I型遗传性运动和感觉神经病（HMSN）患者，他们在慢性腓骨肌萎缩的基础上，数月内出现了明显的肌无力。进一步检查发现，其中1例患者患有慢性炎症性脱髓鞘性多发性神经根神经病（CIDP），另一例患者患有与多发性肌炎相关的CIDP。两名患者对泼尼松和硫唑嘌呤治疗反应良好，病情有显著改善。对于肌无力快速进展的HMSN患者，应评估是否并发了潜在可治疗的免疫性神经肌肉疾病。
