通过导入T细胞受体基因将1型人类免疫缺陷病毒的特异性转移到原代人类T淋巴细胞中。
Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes.
作者信息
Cooper L J, Kalos M, Lewinsohn D A, Riddell S R, Greenberg P D
机构信息
Program in Immunology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA. lcooper
出版信息
J Virol. 2000 Sep;74(17):8207-12. doi: 10.1128/jvi.74.17.8207-8212.2000.
Abstract
The introduction of genes encoding T-cell receptor (TCR) chains specific for human immunodeficiency virus into T cells of infected patients represents a means to quantitatively and qualitatively improve immunity to the virus. Our results demonstrate that the high level of TCR expression required for physiologic functioning can be reproducibly achieved with retroviral vectors encoding full-length unmodified TCR chains under the control of a strong internal constitutive phosphoglycerate kinase promoter.
摘要
将编码针对人类免疫缺陷病毒的T细胞受体（TCR）链的基因导入受感染患者的T细胞，是一种在数量和质量上提高对该病毒免疫力的方法。我们的结果表明，在强大的内部组成型磷酸甘油酸激酶启动子控制下，用编码全长未修饰TCR链的逆转录病毒载体可以可重复地实现生理功能所需的高水平TCR表达。
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