Mediavilla C, Molina F, Puerto A
Area de Psicobiología, Departamento de Psicología Experimental y Fisiología del Comportamiento, Universidad de Granada, Campus de Cartuja, Granada 18071, Spain.
Neurobiol Learn Mem. 2000 Sep;74(2):105-18. doi: 10.1006/nlme.1999.3941.
Bilateral electrolytic lesions in the pedunculopontine nucleus (PPN) impair acquisition of short-term, or concurrent, Taste Aversion Learning (TAL) in rats. This type of TAL is characterized by the daily presentation of two different flavor stimuli at the same time, one associated with simultaneous intragastric administration of an aversive product (hypertonic NaCl) and the other with physiological saline. Sham-lesioned control animals learn this taste discrimination task, but both lesioned animals and control animals learn a long-term, or delayed, TAL task in which each gustatory stimulus is presented individually every other day and the intragastric products, LiCl (0.15 M) and physiological saline, are administered after a 15-min delay. These results are analyzed in the context of the cerebellar circuits involved in learning and in relation to the two TAL modalities described above.
脑桥脚核（PPN）的双侧电解损伤会损害大鼠短期或同时性味觉厌恶学习（TAL）的习得。这种类型的TAL的特点是每天同时呈现两种不同的味觉刺激，一种与同时胃内注射厌恶产物（高渗氯化钠）相关，另一种与生理盐水相关。假手术对照动物能学会这种味觉辨别任务，但损伤动物和对照动物都能学会长期或延迟性TAL任务，在该任务中，每隔一天分别呈现每种味觉刺激，胃内产物氯化锂（0.15M）和生理盐水在延迟15分钟后给药。在参与学习的小脑回路背景下，并结合上述两种TAL模式对这些结果进行了分析。
