Mediavilla Cristina, Bernal Antonio, Puerto Amadeo
Departamento de Psicología Experimental y Fisiología del Comportamiento, Campus de Cartuja, University of Granada, 18071 Granada, Spain.
Neurobiol Learn Mem. 2007 Sep;88(2):264-8. doi: 10.1016/j.nlm.2007.05.008. Epub 2007 Jul 16.
Taste aversion learning (TAL) can be induced by associating a flavor intake with the immediate or delayed (30 min) intragastric administration of a noxious substance, e.g., hypertonic NaCl. The objective of this study was to analyze the induction of c-Fos immunoreactivity in the intermediate nucleus of the solitary nucleus (iNST) after acquisition of a contiguous or delayed TAL, offering the flavor for voluntary consumption in both cases. The behavioral results obtained indicate that, although the learning was established under both experimental conditions, an increase in c-Fos induction was only produced in the group that learned by means of a non-delayed TAL. Immunohistochemical analyses revealed the participation of different brain structures in these two TAL modalities. Thus, the nucleus of the solitary tract may be involved in the TAL procedure in which voluntary flavor intake and intragastric administration of the noxious visceral stimulus are contiguous but not in delayed TAL, which would depend on other anatomical circuits that do not include the iNST.
味觉厌恶学习（TAL）可通过将一种味道摄入与立即或延迟（30分钟）胃内给予有害物质（如高渗氯化钠）相关联来诱导。本研究的目的是分析在获得连续或延迟的味觉厌恶学习后，孤束核中间核（iNST）中c-Fos免疫反应性的诱导情况，在两种情况下都提供味道以供自愿摄取。所获得的行为结果表明，尽管在两种实验条件下都建立了学习，但仅在通过非延迟味觉厌恶学习的组中产生了c-Fos诱导的增加。免疫组织化学分析揭示了不同脑结构在这两种味觉厌恶学习模式中的参与。因此，孤束核可能参与了味觉厌恶学习过程，在该过程中，自愿味道摄取和有害内脏刺激的胃内给予是连续的，但不参与延迟味觉厌恶学习，延迟味觉厌恶学习将依赖于不包括孤束核中间核的其他解剖回路。
