神经营养因子与神经元细胞骨架的动态调节

Neurotrophins and the dynamic regulation of the neuronal cytoskeleton.

作者信息

Gallo G, Letourneau P C

机构信息

Department of Neuroscience, 6-145 Jackson Hall, University of Minnesota, Minneapolis, Minnesota 55455, USA.

出版信息

J Neurobiol. 2000 Aug;44(2):159-73. doi: 10.1002/1097-4695(200008)44:2<159::aid-neu6>3.0.co;2-h.

DOI:10.1002/1097-4695(200008)44:2<159::aid-neu6>3.0.co;2-h

PMID:10934319

Abstract

The morphology of neuronal axons and dendrites is dependent on the dynamics of the cytoskeleton. An understanding of neurodevelopment and adult neuroplasticity must therefore include a detailed description of the intrinsic and extrinsic mechanisms that regulate the organization and dynamics of actin filaments and microtubules. In this paper we review recent advances in the understanding of the dynamic regulation of neuronal morphology by interactions among cytoskeletal components and the regulation of the cytoskeleton by neurotrophins.

摘要

神经元轴突和树突的形态取决于细胞骨架的动力学。因此，对神经发育和成人神经可塑性的理解必须包括对调节肌动蛋白丝和微管的组织及动力学的内在和外在机制的详细描述。在本文中，我们综述了关于细胞骨架成分之间的相互作用对神经元形态的动态调节以及神经营养因子对细胞骨架的调节方面的最新进展。