Dent Erik W, Gertler Frank B
Biology Department, 68-270, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Neuron. 2003 Oct 9;40(2):209-27. doi: 10.1016/s0896-6273(03)00633-0.
Recent studies indicate the actin and microtubule cytoskeletons are a final common target of many signaling cascades that influence the developing neuron. Regulation of polymer dynamics and transport are crucial for the proper growth cone motility. This review addresses how actin filaments, microtubules, and their associated proteins play crucial roles in growth cone motility, axon outgrowth, and guidance. We present a working model for cytoskeletal regulation of directed axon outgrowth. An important goal for the future will be to understand the coordinated response of the cytoskeleton to signaling cascades induced by guidance receptor activation.
近期研究表明，肌动蛋白和微管细胞骨架是许多影响发育中神经元的信号级联反应的最终共同靶点。聚合物动力学和运输的调节对于生长锥的正常运动至关重要。本综述探讨了肌动蛋白丝、微管及其相关蛋白如何在生长锥运动、轴突生长和导向中发挥关键作用。我们提出了一个用于定向轴突生长的细胞骨架调节的工作模型。未来的一个重要目标将是了解细胞骨架对由导向受体激活诱导的信号级联反应的协调反应。
