Figueirôa F L, Andrade Filho A S, Crvalho E S, Brites C, Badaró R
Institute, Bahia Medical and Public Health School, University Hospital Prof. Edgard Santos - Laboratory of Retrovirus - Federal University of Bahia, Salvador, BA, Brazil.
Braz J Infect Dis. 2000 Jun;4(3):126-30.
The prevalence of HTLV-I reaches 1.8% among blood donors in Salvador, and 40% among chronic myelopathy patients in the state of Bahia, Brazil. The present study shows the epidemiological and clinical picture of patients attending the HAM/TSP Outpatient Unit at the Foundation of Neurology and Neorusurgery (FNN). 114 patients had epidemiologic data collected and 51 of these patients, who had regularly attended the HAM/TSP Unit for at least 1 year, were evaluated for signs, symptoms and disease progression. Most of the 114 patients were female (70%), of African descent, and with a mean age of 51. Sexually transmitted diseases and blood transfusion were the most common risk factors. Paraparesis with spasticity was the predominant sign (85%), bladder dysfunction occurred in 75%, intestinal dysfunction was recorded in 48%. Sensory examination was normal in 50% of the cases studied. The patients' functional status, as measured by the Kurtzke Disability Scale, during the 1 year observation period changed only in early disease. Steroid therapy with prednisone was the most commonly used treatment in this group.
在巴西巴伊亚州萨尔瓦多的献血者中，人类嗜T淋巴细胞病毒I型（HTLV-I）的流行率达1.8%，在慢性脊髓病患者中达40%。本研究展示了在神经学与神经外科学基金会（FNN）的HAM/TSP门诊就诊的患者的流行病学和临床情况。收集了114例患者的流行病学数据，其中51例至少在HAM/TSP科室定期就诊1年，对其体征、症状及疾病进展进行了评估。114例患者中大多数为女性（70%），非洲裔，平均年龄51岁。性传播疾病和输血是最常见的危险因素。伴有痉挛的双下肢轻瘫是主要体征（85%），75%的患者出现膀胱功能障碍，48%记录有肠道功能障碍。在所研究的病例中，50%的患者感觉检查正常。根据Kurtzke残疾量表测量，患者在1年观察期内的功能状态仅在疾病早期发生变化。该组最常用的治疗方法是泼尼松类固醇疗法。
