Iwahashi K, Shida T, Asada T, Higami T, Obo H, Nohara H, Yamashita T, Wakiyama H, Kozawa S, Ogawa K
Department of Cardiovascular Surgery, Hyogo Brain and Heart Center at Himeji, Japan.
Kyobu Geka. 2000 Jul;53(8 Suppl):617-21.
A total of fourteen patients with combined operation of coronary artery bypass grafting (CABG) and aortic valve replacement (AVR) for coronary artery disease (CAD) and aortic stenosis (AS) were reviewed to evaluate the indication of the combined operation. Preoperative pressure gradient across the valve and effective orifice area were 21-89 mmHg (mean 64 mmHg), 0.5-1.9 cm2 (mean 0.92 cm2), respectively. The extent of CAD was 1-3 (mean 2.0). Fractional shortening (%FS) ranged from 13% to 43% with mean value of 28%. All patients underwent CABG and AVR. The number of grafts was 1-4 (mean 2.3) with internal thoracic artery used in 7 cases. Mechanical valves were employed for all patients except 1 case with cerebral aneurysm. There was no operative death, although low output syndrome developed in 2 cases. One had poor left ventricular function preoperatively, and the other was emergency case. Fractional shortening improved postoperatively even in two cases with preoperative %FS less than 20%, and all grafts were patent on postoperative coronary angiography. The event-free survival was 100% during 32 months of mean follow-up. Combined AVR with CABG is recommended to avoid risky secondary operation in patients of CAD and AS, even if one of which is relatively mild, because of the fact that operative and late results of the combined surgery are satisfactory.
回顾了14例因冠状动脉疾病(CAD)和主动脉瓣狭窄(AS)而接受冠状动脉旁路移植术(CABG)和主动脉瓣置换术(AVR)联合手术的患者,以评估联合手术的适应症。术前瓣膜两端的压力阶差和有效瓣口面积分别为21-89 mmHg(平均64 mmHg)、0.5-1.9 cm²(平均0.92 cm²)。CAD的范围为1-3(平均2.0)。左室短轴缩短率(%FS)为13%至43%,平均值为28%。所有患者均接受了CABG和AVR。移植血管数量为1-4(平均2.3),其中7例使用了胸廓内动脉。除1例患有脑动脉瘤的患者外,所有患者均使用了机械瓣膜。尽管有2例出现低心排综合征,但无手术死亡病例。1例术前左心室功能较差,另1例为急诊病例。即使是术前%FS小于20%的2例患者,术后左室短轴缩短率也有所改善,术后冠状动脉造影显示所有移植血管均通畅。平均随访32个月期间,无事件生存率为100%。对于CAD和AS患者,即使其中一项病情相对较轻,也建议进行AVR与CABG联合手术,以避免二次手术的风险,因为联合手术的手术效果和远期效果均令人满意。