Davis J S, Lie J T
Arch Pathol. 1975 May;99(5):278-82.
Intracellular and extracellular glomerular microparticles (GMP) have been described in diverse human glomerulopathies. We have recently detected extracellular GMP in two heroin abusers with nephrotic syndrome. Most of the GMP were approximately 100 nm in diameter (range, 56 to 178 nm), and consisted ultrastructurally of an electron-dense central core surrounded by a concentric, lucent area and an electron-dense limiting membrane. Incomplete forms of GMP and residual laminated membranes without a central core were also present. The distribution of extracellular GMP was both intramembranous and subepithelial; they did not resemble virions morphologically. As these GMP have been observed in human glomerulopathies that are etiologically and morphologically varied, they probably represent nonspecific markers of glomerular injury. The prevalence of GMP in the nephrotic syndrome of heroin abusers awaits cumulative experience.
细胞内和细胞外肾小球微粒（GMP）已在多种人类肾小球疾病中被描述。我们最近在两名患有肾病综合征的海洛因滥用者中检测到了细胞外GMP。大多数GMP直径约为100纳米（范围为56至178纳米），超微结构上由一个电子致密的中央核心组成，周围是一个同心的透明区域和一个电子致密的限制膜。也存在不完整形式的GMP和没有中央核心的残留层状膜。细胞外GMP的分布既有膜内的也有上皮下的；它们在形态上与病毒粒子不同。由于这些GMP已在病因和形态各异的人类肾小球疾病中被观察到，它们可能代表肾小球损伤的非特异性标志物。海洛因滥用者肾病综合征中GMP的患病率有待积累经验。
