Nauta J, de Heer E, Baldwin W M, ten Kate F J, v d Heijden A J, Wolff E D
Department of Paediatrics, Sophia Children's Hospital, Erasmus University Medical School, Rotterdam, The Netherlands.
Pediatr Nephrol. 1990 Mar;4(2):111-6. doi: 10.1007/BF00858820.
We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies.
我们报告了一例因膜性肾小球肾炎导致的新生儿肾衰竭病例。该患者在出生后的前三周无尿，之后肾功能恢复。母亲的血清中含有IgG抗体，该抗体可与成人及胎儿人类肾脏的肾小管刷状缘和肾小球发生反应。检测到与人类肾脏肾上皮的反应性。我们认为，尽管所涉及的抗原并非gp 330或任何已知参与实验性肾病的肾脏抗原，但经胎盘的被动性海曼肾炎样机制是新生儿症状的发病原因。
