Efficacy of malononitriloamide 279 and 715 in islet xenotransplantation: a study in the pig-to-rat model.
作者信息
Wijkström M, Song Z, Zhang J, Bari S, Sundberg B, Groth C G, Korsgren O, Wennberg L
机构信息
Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden.
出版信息
Transplant Proc. 2000 Aug;32(5):1024. doi: 10.1016/s0041-1345(00)01095-2.
Abstract
摘要
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Efficacy of malononitriloamide 279 and 715 in islet xenotransplantation: a study in the pig-to-rat model.
Transplant Proc. 2000 Aug;32(5):1024. doi: 10.1016/s0041-1345(00)01095-2.
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Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice.
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The efficacy of CD40 ligand blockade in discordant pig-to-rat islet xenotransplantation is correlated with an immunosuppressive effect of immunoglobulin.CD40配体阻断在猪到大鼠异种胰岛移植中的疗效与免疫球蛋白的免疫抑制作用相关。
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Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine, mycophenolate mofetil, and leflunomide remain normoglycemic for up to 100 days.移植了成年猪胰岛并用环孢素、霉酚酸酯和来氟米特进行免疫抑制的糖尿病大鼠可维持长达100天的血糖正常。
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