Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice.
作者信息
Gysemans C, Waer M, Laureys J, Bouillon R, Mathieu C
机构信息
Department of Experimental Medicine and Endocrinology (LEGENDO), Catholic University of Leuven, Campus Gaithuisberg, Leuven, Belgium.
出版信息
Transplant Proc. 2001 May;33(3):2094-5. doi: 10.1016/s0041-1345(01)01961-3.
Abstract
摘要
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Leflunomide and its analogue X920715 synergize with cyclosporin A in preventing early graft failure and delaying graft rejection of xenogeneic islets in nonobese diabetic mice.
Transplant Proc. 2001 May;33(3):2094-5. doi: 10.1016/s0041-1345(01)01961-3.
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Long-term xenograft survival by combination therapy of malononitrilamide MNA 715 with cyclosporine.
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Triple drug treatment with cyclosporine, leflunomide and mycophenolate mofetil prevents rejection of pig islets transplanted into rats and primates.
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Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice.免疫抑制可防止协调性异种胰岛移植排斥反应，但不足以防止非肥胖糖尿病小鼠自身免疫性糖尿病的复发。
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Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents.通过抗炎药物预防自身免疫性糖尿病NOD小鼠胰岛异种移植的原发性无功能。
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