Choi J H, Kim D
Faculty of Food Science and Biotechnology, Pukyong National University; 599-1 Daeyeon-Dong, Nam-Gu, Pusan 608-737, Korea.
J Nutr Health Aging. 2000;4(3):182-6.
This study was to evaluate the effect of dietary restriction (DR) on lifespan and oxidative stress of dementia mouse model SAMP8 with impaired learning and memory. SAMP8 female mice were fed either ad libitum (AL) or fed 60% of food intake of AL. Results showed that basal metabolic rates (BMR) were significantly lower (15 to 22%) in DR with increased median and maximum lifespans, suggesting feed and gross efficiencies were significantly lower in DR than in AL. Grading score of senescence resulted in a marked improvement about 2-fold by DR compared with AL. The amounts of lipofuscin at 12 months were significantly lowered 16% in DR than that of AL. Median and maximal lifespans significantly increased (28.5% and 16.4%, respectively) by DR, and also lowered superoxide radical about 15 approximately 45% in DR compared with AL at 4, 8 and 12 months of age. On the other hand, superoxide dismutase (SOD) activities were higher (about 15 approximately 30%) in DR than those in AL group of SAMP8 except for 4 months of age. Our results suggest that 40% calorie restricted SAMP8 can effectively suppress dementia-related abnormalities during aging.
本研究旨在评估饮食限制（DR）对学习和记忆受损的痴呆小鼠模型SAMP8的寿命和氧化应激的影响。将SAMP8雌性小鼠分为自由采食组（AL）和采食AL组食物摄入量60%的限制饮食组。结果显示，限制饮食组的基础代谢率（BMR）显著降低（15%至22%），同时中位寿命和最大寿命延长，这表明限制饮食组的饲料效率和总效率显著低于自由采食组。与自由采食组相比，限制饮食组的衰老分级评分显著改善了约2倍。12个月时，限制饮食组的脂褐素含量比自由采食组显著降低了16%。限制饮食使中位寿命和最大寿命显著延长（分别延长28.5%和16.4%），并且在4、8和12月龄时，与自由采食组相比，限制饮食组的超氧自由基含量降低了约15%至45%。另一方面，除4月龄外，限制饮食组SAMP8的超氧化物歧化酶（SOD）活性高于自由采食组（约高15%至30%）。我们的结果表明，40%热量限制的SAMP8可以有效抑制衰老过程中与痴呆相关的异常。
