日裔美国老年男性饮酒与认知能力的纵向研究：檀香山-亚洲老年研究
A longitudinal study of drinking and cognitive performance in elderly Japanese American men: the Honolulu-Asia Aging Study.
作者信息
Galanis D J, Joseph C, Masaki K H, Petrovitch H, Ross G W, White L
机构信息
National Institute on Aging, National Institutes of Health, Bethesda, Md., USA.
出版信息
Am J Public Health. 2000 Aug;90(8):1254-9. doi: 10.2105/ajph.90.8.1254.
OBJECTIVES
This study prospectively describes the relationships between alcohol intake and subsequent cognitive performance among participants in the Honolulu Heart Program (HHP).
METHODS
Alcohol intake was assessed at Exam III of the HHP, and cognitive performance was measured approximately 18 years later with the Cognitive Abilities Screening Instrument (CASI). Complete information was available for 3556 participants, aged 71 to 93 years at follow-up.
RESULTS
In multivariate analyses, the relationship between drinking and later cognitive performance appeared nonlinear, as nondrinkers and heavy drinkers (more than 60 ounces of alcohol per month) had the lowest CASI scores and the highest risks of poor and intermediate CASI outcomes. Compared with nondrinkers, the risk of a poor CASI score was lowered by 22% to 40% among men who consumed 1-60 ounces of alcohol per month.
CONCLUSIONS
We report a positive association between moderate alcohol intake among middle-aged men and subsequent cognitive performance in later life. However, it is possible that the health risks associated with drinking outweight any potential benefits for many elderly persons.
目的
本研究前瞻性地描述了檀香山心脏项目（HHP）参与者的酒精摄入量与随后认知表现之间的关系。
方法
在HHP的第三次检查中评估酒精摄入量，并在大约18年后使用认知能力筛查工具（CASI）测量认知表现。共有3556名参与者在随访时年龄为71至93岁，他们提供了完整信息。
结果
在多变量分析中，饮酒与后期认知表现之间的关系呈非线性，因为不饮酒者和大量饮酒者（每月超过60盎司酒精）的CASI得分最低，且CASI结果为差和中等的风险最高。与不饮酒者相比，每月饮用1 - 60盎司酒精的男性中，CASI得分差的风险降低了22%至40%。
结论
我们报告中年男性适度饮酒与晚年随后的认知表现之间存在正相关。然而，对于许多老年人来说，饮酒相关的健康风险可能超过任何潜在益处。
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