Department of Geriatric Medicine, John A. Hartford Center of Excellence in Geriatrics, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
J Am Geriatr Soc. 2014 May;62(5):880-8. doi: 10.1111/jgs.12796. Epub 2014 Apr 29.
To identify potentially modifiable late-life biological, lifestyle, and sociodemographic factors associated with overall and healthy survival to age 85.
Prospective longitudinal cohort study with 21 years of follow-up (1991-2012).
Hawaii Lifespan Study.
American men of Japanese ancestry (mean age 75.7, range 71-82) without baseline major clinical morbidity and functional impairments (N = 1,292).
Overall survival and healthy survival (free from six major chronic diseases and without physical or cognitive impairment) to age 85. Factors were measured at late-life baseline examinations (1991-1993).
Of 1,292 participants, 1,000 (77%) survived to 85 (34% healthy) and 309 (24%) to 95 (<1% healthy). Late-life factors associated with survival and healthy survival included biological (body mass index, ankle-brachial index, cognitive score, blood pressure, inflammatory markers), lifestyle (smoking, alcohol use, physical activity), and sociodemographic factors (education, marital status). Cumulative late-life baseline risk factor models demonstrated that age-standardized (at 70) probability of survival to 95 ranged from 27% (no factors) to 7% (≥ 5 factors); probability of survival to 100 ranged from 4% (no factors) to 0.1% (≥ 5 factors). Age-standardized (at 70) probability of healthy survival to 90 ranged from 4% (no factors) to 0.01% (≥ 5 factors). There were nine healthy survivors at 95 and one healthy survivor at 100.
Several potentially modifiable risk factors in men in late life (mean age 75.7) were associated with markedly greater probability of subsequent healthy survival and longevity.
确定与 85 岁时总生存和健康生存相关的潜在可改变的老年生物、生活方式和社会人口因素。
前瞻性纵向队列研究，随访 21 年（1991-2012 年）。
夏威夷寿命研究。
无基线主要临床疾病和功能障碍的日本裔美国男性（平均年龄 75.7 岁，范围 71-82 岁）（N=1292）。
85 岁时的总生存和健康生存（无六种主要慢性疾病，无身体或认知障碍）。在老年基线检查时（1991-1993 年）测量了因素。
在 1292 名参与者中，有 1000 名（77%）存活至 85 岁（34%健康），309 名（24%）存活至 95 岁（<1%健康）。与生存和健康生存相关的老年因素包括生物学因素（体重指数、踝臂指数、认知评分、血压、炎症标志物）、生活方式因素（吸烟、饮酒、身体活动）和社会人口因素（教育、婚姻状况）。累积的老年基线风险因素模型表明，按年龄标准化（70 岁），存活至 95 岁的概率从 27%（无因素）到 7%（≥5 个因素）；存活至 100 岁的概率从 4%（无因素）到 0.1%（≥5 个因素）。按年龄标准化（70 岁），健康存活至 90 岁的概率从 4%（无因素）到 0.01%（≥5 个因素）。有 9 名健康幸存者存活至 95 岁，1 名健康幸存者存活至 100 岁。
在老年男性中（平均年龄 75.7 岁），几个潜在的可改变的危险因素与随后的健康生存和长寿有显著的更大的可能性相关。
