Seeck M, Lazeyras F, Murphy K, Naimi A, Pizzolatto G P, de Tribolet N, Delavelle J, Villemure J G, Landis T
Department of Neurology, University Hospital of Geneva, Switzerland.
Epileptic Disord. 1999 Sep;1(3):179-85.
MRI volumetric measurements of the ipsi- and contralateral hippocampal volume (HV) were performed in a group of 37 patients with lesional and non-lesional temporal (TLE), and extratemporal lobe (ETLE) lobe epilepsy. Twenty-six patients underwent surgery and the resected tissues subjected to histopathological examination. Psychosocial scores were calculated on the basis of employment, partnership/family status and presence of a positive psychiatric history. Poorest values were obtained for the group with right lesional and non-lesional TLE (RTLE, p < 0.001). In this group, significant positive correlations between psychosocial functioning and the left hippocampal volume or age of onset were observed. We found that the left hippocampal volume in RTLE was smaller with increasing epilepsy duration. We conclude that patients with RTLE represent a particular group with regard to the structural and psychosocial consequences of chronic epilepsy. With regard to histopathological analysis, no particular type of lesion was identified as the major determinant of the results described above.
对37例患有颞叶（TLE）和颞叶外（ETLE）病灶性和非病灶性癫痫的患者进行了磁共振成像（MRI）对同侧和对侧海马体积（HV）的容积测量。26例患者接受了手术，切除的组织进行了组织病理学检查。根据就业情况、伴侣/家庭状况和是否有阳性精神病史计算社会心理评分。右侧病灶性和非病灶性颞叶癫痫（RTLE）组的评分最差（p<0.001）。在该组中，观察到社会心理功能与左侧海马体积或发病年龄之间存在显著正相关。我们发现，RTLE患者的左侧海马体积随着癫痫持续时间的增加而减小。我们得出结论，就慢性癫痫的结构和社会心理后果而言，RTLE患者代表了一个特殊的群体。关于组织病理学分析，未发现特定类型的病变是上述结果的主要决定因素。
