Stein J H, Kirschenbaum M A, Bay W H, Osgood R W, Ferris T F
Circ Res. 1975 Jun;36(6 Suppl 1):119-24. doi: 10.1161/01.res.36.6.119.
A large body of evidence has accumulated which demonstrates that sodium transport in some distal nephron segment is altered in response to changes in extracellular fluid volume. Sodium reabsorption in the loop of Henle and distal tubule is directly related to delivery rate and is not inhibited by volume expansion. In contrast, recent studies have shown that Ringer loading causes a greater natriuretic response than hyperoncotic albumin because of diminished collecting duct sodium transport in the former model. Additional studies in animals with different basal extracellular fluid volumes and in DOCA-escape rats indicate further that the collecting duct is an important regulator of sodium balance. Although the factors that modulate sodium transport in the collecting duct are not clear, it is postulated that the local release of prostaglandins may be of major importance.
大量证据已经积累起来，表明在一些远端肾单位节段中，钠转运会随着细胞外液量的变化而改变。亨利氏袢和远端小管中的钠重吸收与输送速率直接相关，并且不受容量扩张的抑制。相比之下，最近的研究表明，由于在前一种模型中集合管钠转运减少，林格氏液负荷比高渗白蛋白引起更大的利钠反应。在具有不同基础细胞外液量的动物和去氧皮质酮逃逸大鼠中的进一步研究表明，集合管是钠平衡的重要调节者。尽管调节集合管中钠转运的因素尚不清楚，但据推测前列腺素的局部释放可能起主要作用。
