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易患高血压和抗高血压的Sabra大鼠对急性盐水负荷的肾脏反应。

Renal response to acute saline loading in Sabra hypertension-prone and -resistant rats.

作者信息

Mekler J, Yagil Y, Ben-Ishay D

出版信息

Experientia. 1985 Jul 15;41(7):923-4. doi: 10.1007/BF01970014.

DOI:10.1007/BF01970014
PMID:4007128
Abstract

The renal handling of an oral isotonic saline load was studied in hypertension-prone (SBH), hypertension-resistant (SBN) and the parental Sabra (SB) rats. The diuretic and natriuretic response of SBH rats was unequivocally diminished, thus lending further support to the concept of impaired salt handling in hypertension.

摘要

对高血压易感（SBH）、抗高血压（SBN）和亲本品系Sabra（SB）大鼠口服等渗盐负荷后的肾脏处理情况进行了研究。SBH大鼠的利尿和排钠反应明显减弱，这进一步支持了高血压中盐处理受损的概念。

相似文献

1
Renal response to acute saline loading in Sabra hypertension-prone and -resistant rats.易患高血压和抗高血压的Sabra大鼠对急性盐水负荷的肾脏反应。
Experientia. 1985 Jul 15;41(7):923-4. doi: 10.1007/BF01970014.
2
Sodium handling by the Sabra hypertension prone (SBH) and resistant (SBN) rats.
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3
Nifedipine corrects the blunted renal response to saline loading in hypertension-prone SBH rats.
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Water handling by the sabra hypertension prone (SBH) and resistant (SBN) rats.
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Disparate expression of the AVP gene in Sabra hypertension-prone and hypertension-resistant rats.精氨酸加压素基因在易患高血压和抗高血压的Sabra大鼠中的差异表达。
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The lack of a modulating effect of non-genetic factors (age, gonads and maternal environment) on the phenotypic expression of the salt-susceptibility genes in the Sabra rat model of hypertension.在高血压的Sabra大鼠模型中，非遗传因素（年龄、性腺和母体环境）对盐敏感性基因表型表达缺乏调节作用。
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Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension.同源近交系证实了高血压Sabra大鼠模型中1号染色体上存在盐敏感性数量性状基因座。
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[Evidence for two alpha 2B-adrenoreceptor isoforms in the renal cortex of salt-sensitive and salt resistant Sabra rats. Effect of salt loading].[盐敏感和盐抵抗型Sabra大鼠肾皮质中两种α2B-肾上腺素能受体亚型的证据。盐负荷的影响]
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本文引用的文献

1
Renal alpha-adrenergic receptor abnormality in the spontaneously hypertensive rat.自发性高血压大鼠的肾α-肾上腺素能受体异常
Hypertension. 1982 Nov-Dec;4(6):881-7. doi: 10.1161/01.hyp.4.6.881.
2
The effects of antidiuretic hormone (ADH) on solute and water transport in the mammalian nephron.抗利尿激素（ADH）对哺乳动物肾单位中溶质和水转运的影响。
J Membr Biol. 1981 Jan 30;58(1):1-19. doi: 10.1007/BF01871030.
3
Exaggerated response to isotonic saline loading in genetically hypertension-prone rats.
J Lab Clin Med. 1973 Oct;82(4):597-604.
4
Separation of two strains of rats with inbred dissimilar sensitivity to Doca-salt hypertension.
Experientia. 1972 Nov 15;28(11):1321-2. doi: 10.1007/BF01965321.
5
Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension.动脉血压调节。在长期调节及高血压中肾脏起主导作用。
Am J Med. 1972 May;52(5):584-94. doi: 10.1016/0002-9343(72)90050-2.
6
Abnormal relationship between sodium excretion and hypertension in spontaneously hypertensive rats.
Pflugers Arch. 1975;354(1):39-53. doi: 10.1007/BF00584502.
7
Changes in renin, water balance, and sodium balance during development of high blood pressure in genetically hypertensive rats.遗传性高血压大鼠高血压发展过程中肾素、水平衡和钠平衡的变化。
Circ Res. 1975 Jun;36(6 Suppl 1):153-61. doi: 10.1161/01.res.36.6.153.
8
Role of the collecting duct in the regulation of sodium balance.集合管在钠平衡调节中的作用。
Circ Res. 1975 Jun;36(6 Suppl 1):119-24. doi: 10.1161/01.res.36.6.119.