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Class II transactivator: mastering the art of major histocompatibility complex expression.

作者信息

Harton J A, Ting J P

机构信息

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

出版信息

Mol Cell Biol. 2000 Sep;20(17):6185-94. doi: 10.1128/MCB.20.17.6185-6194.2000.

DOI:10.1128/MCB.20.17.6185-6194.2000
PMID:10938095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC86093/
Abstract
摘要

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本文引用的文献

1
Molecular genetics of the Bare lymphocyte syndrome.裸淋巴细胞综合征的分子遗传学
Rev Immunogenet. 2000;2(2):267-82.
2
Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter.转录支架：CIITA与NF-Y、RFX和CREB相互作用，以对II类主要组织相容性复合体启动子进行立体特异性调控。
Mol Cell Biol. 2000 Aug;20(16):6051-61. doi: 10.1128/MCB.20.16.6051-6061.2000.
3
Identification of class II transcriptional activator-induced genes by representational difference analysis: discoordinate regulation of the DN alpha/DO beta heterodimer.通过代表性差异分析鉴定II类转录激活因子诱导的基因：DNα/DOβ异二聚体的失调调节
J Immunol. 2000 Aug 1;165(3):1410-6. doi: 10.4049/jimmunol.165.3.1410.
4
CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex.CIITA是一种转录共激活因子，它通过与增强体复合物的多种协同相互作用被招募到MHC II类启动子上。
Genes Dev. 2000 May 1;14(9):1156-66.
5
A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.RFX5的一个功能必需结构域通过促进RFX与NF-Y之间的协同结合来介导主要组织相容性复合体II类启动子的激活。
Mol Cell Biol. 2000 May;20(10):3364-76. doi: 10.1128/MCB.20.10.3364-3376.2000.
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Cutting edge: activation of HIV-1 transcription by the MHC class II transactivator.
J Immunol. 2000 Apr 15;164(8):3941-5. doi: 10.4049/jimmunol.164.8.3941.
7
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.在HIV感染中，反式激活转录蛋白（Tat）与Ⅱ类主要组织相容性复合体反式激活因子（CIITA）竞争结合正性转录延伸因子b（P-TEFb），并阻断MHCⅡ类基因的表达。
Immunity. 2000 Jan;12(1):61-70. doi: 10.1016/s1074-7613(00)80159-4.
8
HLA polymorphisms and T cells in rheumatoid arthritis.类风湿关节炎中的HLA多态性与T细胞
Int Rev Immunol. 1999;18(1-2):37-59. doi: 10.3109/08830189909043018.
9
MHC class II regulation in vivo in the mouse kidney.小鼠肾脏中MHC II类分子在体内的调控
Microbes Infect. 1999 Sep;1(11):903-12. doi: 10.1016/s1286-4579(99)00227-0.
10
Regulation of MHC class II expression in the central nervous system.
Microbes Infect. 1999 Sep;1(11):893-902. doi: 10.1016/s1286-4579(99)00228-2.