Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239, USA.
Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, OR 97239, USA.
Biophys Chem. 2022 May;284:106781. doi: 10.1016/j.bpc.2022.106781. Epub 2022 Feb 15.
The major histocompatibility complex (MHC) spans innate and adaptive immunity by presenting antigenic peptides to CD4 and CD8 T cells. Multiple transcription factors form an enhanceosome complex on the MHC promoter and recruit transcriptional machinery to activate gene transcription. Immune signals such as interferon-γ (IFN-γ) control MHC level by up-regulating components of the enhanceosome complex. As MHC plays crucial roles in immune regulation, alterations in the MHC enhanceosome structure will alter the pace of rapid immune responses at the transcription level and lead to various diseases related to the immune system. In this review, we discuss the current understanding of the MHC enhanceosome, with a focus on the structures of MHC enhanceosome components and the molecular basis of MHC enhanceosome assembly.
主要组织相容性复合体 (MHC) 通过向 CD4 和 CD8 T 细胞呈递抗原肽来跨越先天和适应性免疫。多个转录因子在 MHC 启动子上形成增强子复合物，并募集转录机制来激活基因转录。干扰素-γ (IFN-γ) 等免疫信号通过上调增强子复合物的组成部分来控制 MHC 水平。由于 MHC 在免疫调节中起着至关重要的作用，因此 MHC 增强子结构的改变将改变转录水平上快速免疫反应的速度，并导致与免疫系统相关的各种疾病。在这篇综述中，我们讨论了对 MHC 增强子的现有理解，重点介绍了 MHC 增强子成分的结构和 MHC 增强子组装的分子基础。
