Hsü S Y, Hsü H F, Penick G D, Hanson H O, Schiller H J, Cheng H F
Int Arch Allergy Appl Immunol. 1979;59(4):383-93. doi: 10.1159/000232285.
Immunoglobulin E (IgE), mast cells, and eosinophils in the skin of rhesus monkeys immunized with highly X-irradiated cercariae of Schistosoma japonicum were studied. IgE was stained by the unlabeled antibody enzyme method and was found on mast cells. Before challenge, mast cells were found only in the dermis. Immediately after the challenge, mast cells were found in both the dermis and epidermis and many of them were degranulated. Soon after, margination and emigration of granulocytes, predominantly eosinophils, occurred along the blood capillaries in the dermis. Gradulally, preivascular infiltration of eosinophils was seen in the dermis and migration of eosinophils from the dermis into the epidermis appeared, resulting in the formation of minute eosinophilic abscesses in the epidermis. In addition, the IgE was found as a thin coat on the integument of the schistosomula. Deteriorated schistosomula were seen amid the eosinophilic abscesses in the epidermis and in eosinophilic infiltrations in the dermis. The present findings suggest the possibility that the reaction of IgE, mast cells, and eosinophils were integrated into one immunological effect, namely the schistosomulicidal action.
对用高度 X 线照射的日本血吸虫尾蚴免疫的恒河猴皮肤中的免疫球蛋白 E（IgE）、肥大细胞和嗜酸性粒细胞进行了研究。IgE 用未标记抗体酶法染色，发现其存在于肥大细胞上。攻击前，肥大细胞仅见于真皮。攻击后即刻，真皮和表皮中均发现有肥大细胞，且许多肥大细胞已脱颗粒。此后不久，粒细胞（主要是嗜酸性粒细胞）沿真皮中的毛细血管出现边缘化和游出。逐渐地，在真皮中可见嗜酸性粒细胞血管周围浸润，且嗜酸性粒细胞从真皮迁移至表皮，导致表皮中形成微小嗜酸性脓肿。此外，在童虫体表发现 IgE 呈薄涂层状。在表皮的嗜酸性脓肿中和真皮的嗜酸性浸润中可见退化的童虫。目前的研究结果提示，IgE、肥大细胞和嗜酸性粒细胞的反应可能整合为一种免疫效应，即杀童虫作用。
